Staff Profile

Jed Goldstone

Preferred Name: Jared Goldstone

Research Specialist

Biology

Email: jgoldstone@whoi.edu

Phone: 508 289 4823

Lab/Group Site: http://www.whoi.edu/page.do?pid=33129

Education

BS 1993 Yale University, Chemistry
SM 1996 MIT, Inorganic Chemistry
PhD 2002 MIT-WHOI Joint Program, Chemical Oceanography

Research Statement

My research is focused on the cytochromes P450 (CYPs, or P450s), a superfamily of heme proteins involved in the oxidative metabolism of various internal and external (endogenous and xenobiotic) chemicals. The natural history of P450s dates back perhaps 3 billion years, and they occur variously in archaea, bacteria, eukaryota, and as we have described, viruses. Functional and evolutionary relationships among the many P450s remain unclear across vertebrate taxa, and more so between vertebrates and invertebrates. I am interested in the evolution of the broad range of metabolism and biosynthesis reactions carried out by P450s. One major area of research we focus on is the potential mismatch between natural P450 capabilities and the occurrence of human-produced pollutant chemicals. Some of the tools we use are genome sequencing and annotation (gene discovery), protein prediction and modeling (in silico methods), protein expression and metabolite analysis (in vitro), and gene knockout and behavioral studies (in vivo studies).

Research Interests

mechanism and evolution of cytochromes P450; ecotoxicology; molecular evolution in marine animals; oxidative stress in aquatic organisms

Awards

National Research Service Award (NIH)

W. M. Marquet Senior Technical Staff Award